The environs around the Protea Hotel Knysna Quays include the Knysna Lagoon and the city itself which offers a great many tourist activities. Other attractions in this region include taking excursions to view the forest elephants and spending time on the many world-class golf courses that dot the region. The Protea Hotel Knysna Quays is along the Garden Route and is accessible by rail or highway from George.

All of the rooms at the Protea Hotel Knysna Quays are air-conditioned. Each of them also contains satellite television service. Wireless Internet connectivity is available in the guestrooms. The rooms are provided with daily newspaper service and the private baths are stocked with toiletries.

The Protea Hotel Knysna Quays is provided with a host of amenities suitable for business and pleasure travelers. There is a restaurant located on the premises which offers a non-smoking area. There is also a bar where guests can go to enjoy a cocktail. Internet connectivity is available in the hotel commons and there are shops located at the establishment.